We studied in vitro attachment, proliferation and survival of adaver skin fibroblasts in collagen\nbands, dermal matrix and cancellous demineralized bone, enriched with platelet components. It\nwas shown, that PRP enhanced revitalization of collagen grafts, especially followed by components\nof activated or freezed platelets. Fibroblasts had the best rate of proliferative activity in response\nto 150 pg platelet derived growth factor (PDGF), released from 100 million platelets with granules\nand measured for 100 Ã?â?? 103 cultivated cells. The use of platelet-derived material could increase\nfibroblast proliferation activity for 1.5 - 3 times in all types of collagen transplants without damage\nor decay of cellââ?¬â?¢s biological value.
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